Serum changes of adiponectin, insulin resistance and their correlation in endometrial cancer patients / 中华妇产科杂志
Chinese Journal of Obstetrics and Gynecology
;
(12): 672-675, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-423624
ABSTRACT
ObjectiveTo explore changes of serum adiponectin and insulin resistance in patients with endometrial cancer and to evaluate the clinical significance and correlation.MethodsThe serum levels ofadiponectinandfastinginsulinweredeterminedbyELISA, electro-chemilluminometryand radioimmunoassay in 35 patients with endometrial cancer [ all patients divided into two groups,A1 group belonged to without postmenopausal when first visiting (n =20),A2 group belonged to postmenopausal when first visiting (n = 15 ) ] and 30 cases of health control.The result of homeostasis nodel assessment-insulin resistance (HOMA-IR) index was calculated.ResultsThe levels of adiponectin in A1 group was lower than that ofhealth control group [(6.7±1.1) versus (10.0 ±1.4) ng/L,P<0.05],and HOMA-IR was higher than that of health control group ( 3.5 ± 1.8 versus 1.1 ± 0.7,P < 0.05 ).While there were not significant difference between A2 group and health control group (P > 0.05 ).Adiponectin and insulin resistance was negatively correlated ( r =- 0.389,P < 0.05 ).Conclusion Adiponectin reducing and insulin resistance in reproductive age patients may be the independent factors to promote endometrial cancers.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Obstetrics and Gynecology
Ano de publicação:
2012
Tipo de documento:
Artigo
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