Angiotensin Ⅱ receptor blocker induces the activation of peroxisome proliferator-activated receptor gamma / 中国糖尿病杂志
Chinese Journal of Diabetes
;
(12): 375-378, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-423685
ABSTRACT
Objective To observe the effect of angiotensin Ⅱ receptor blockers(ARBs)on peroxisome proliferator-activated receptor gamma(PPAR-γ)and to explore its mechanism for improving glucose and lipids metabolism.Methods Dual-luciferase gene reporting system was used to reflect PPAR-γ promoter activation by irbesartan and telmisartan.RT-PCR was used to reflect PPAR-γ mRNA by activation of irbesartan and telmisartan.Results Irbesartan and telmisartan may increase COS-7 cells PPAR-γ promoter expression and increase 3T3-L1 cells PPAR-γ mRNA expression in dose and time-dependent manners.Conclusions ARB may activate PPARs system to play a role in improving the glucose and lipids metabolism
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Diabetes
Ano de publicação:
2008
Tipo de documento:
Artigo
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