Genetic Modification of Baculovirus Expression Vectors / 中国病毒学·英文版
Virologica Sinica
;
(6): 71-82, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-423975
ABSTRACT
As a protein expression vector,the baculovirus demonstrates many advantages over other vectors.With the development of biotechnology,baculoviral vectors have been genetically modified to facilitate high level expression of heterologous proteins in both insect and mammalian cells.These modifications include utilization of different promoters and signal peptides,deletion or replacement of viral genes for increasing protein secretion,integration of polycistronic expression cassette for producing protein complexes,and baculovirus pseudotyping,promoter accommodation or surface display for enhancing mammalian cell targeting gene delivery.This review summarizes the development and the current state of art of the baculovirus expression system.Further development of baculovirus expression systems will make them even more feasible and accessible for advanced applications.
Texto completo:
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Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Virologica Sinica
Ano de publicação:
2012
Tipo de documento:
Artigo
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