Racial difference in aldose reductase C-106T genetic polymorphism and association with essential hypertension / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 156-160, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-423993
ABSTRACT
Objective:
To investigate the distribution of aldose reductase (AR) C-106T genetic polymorphism in Chinese Han population and its association with the risk for essential hypertension (EH).Methods:
The AR C-106T polymorphism was genotyped in 148 Chinese EH patients and 137controls by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).The genotype distribution between groups was contrasted by x2- test and the degree of genetic association was evaluated by 95% confidence interval (CI).Results:
Frequency of the variant AR C-106T allele was 13.9% (95% CI11.2%-16.6%) in the controls,which was significantly lower than that in the Japanese (18.4% in 712 individuals,P=0.0063),the Australians (37.9% in 240 individuals,P<0.0001) and the Brazilians (34.7% in 62individuals,P< 0.0001).The frequency ofAR C-106T allele was 11.7% (95% CI7.9%-15.5%)in the EH patients.No significant difference in the allele frequency was observed between the EH patients and the controls (P=0.147).Conclusion:
There is obvious racial difference in the distribution of AR C-106T polymorphism.The polymorphism is not associated with the risk for EH.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2012
Tipo de documento:
Artigo
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