Role of N-cadherin in cranial neural crest delamination during chick embryogenesis / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12): 1269-1274, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-424007
ABSTRACT
AIM:
To investigate the role of N-cadherin in the delamination of neural crest cells.METHODS:
The normal expression of N-cadherin in neural tube was identified using in situ hybridization. The cells with N-cadherin over expression were obtained by transfection of wild-type N-cadherin (wt-N-cadherin) ,and the cells with N-cadherin silencing expression were obtained by transfection of dominant-negative N-cadherin (dn-N-cadherin). The migration of cranial neural crest cells was determined by the technique of immunohistochemistry.RESULTS:
Either overexpression or down-regulation of N-cadherin significantly affected the migration of cranial neural crest cells.CONCLUSION:
Delamination and migration of the cranial neural crest cells rely on the relative N-cadherin expression in the neural tube during neurulation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Pathophysiology
Ano de publicação:
2012
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS