Correlation between serum vascular endothelial cells cadherin level and atherosclerosis in diabetic patients / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism
;
(12): 641-643, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-424259
ABSTRACT
To investigate the relationship among serum vascular endothelial cells(VE) -cadherin, advanced glycation end-products( AGE), and atherosclerotic lesion. 20 healthy subjects and 60 patients with diabetes mellitus,including 30 patients with carotid atherosclerosis (CI), were enrolled.Soluble VE-cadherin and AGE were determined using the enzyme-linked immunosorbent method (ELISA). The relationships among the concentration of soluble VE-cadherin, AGE, and the course of the disease, blood glucose, and blood lipid levels were analyzed with multivariant stepwise regression analysis. The levels of serum VE-cadherin and AGE in the patients with diabetes and CI were higher than those in control group( P<0. 05 ). There was a significant difference in VE-cadherin between the diabetes group and the CI group( P<0. 05 ). Serum VE-cadherin levels were positively correlated with serum AGE levels(r = 0. 69, P<0. 01 ). AGE levels were positively correlated with the diabetes duration ( r = 0. 31, P =0. 02 ). The levels of serum VE-cadherin in diabetic patients are positively correlated with their serum AGE levels. The VE-cadherin seems to play an important role in the development of atherosclerosis caused by AGE.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Endocrinology and Metabolism
Ano de publicação:
2011
Tipo de documento:
Artigo
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