Effects of high glucose on the expression of angiotensin-converting enzyme/angiotensin converting enzyme 2 in human proximal tubular cells / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism
;
(12): 680-682, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-424335
ABSTRACT
HK-2 cells cultured in vitro were divided into three groups normal glucose group ( NG ), high glucose group( HG), and mannitol group(MG). The expression of angiotensin-converting enzyme( ACE ) and ACE2 mRNA in HK-2 cells was detected. The concentration of angiotensin Ⅱ ( Ang Ⅱ ) in the culture medium was detected. The mRNA and protein expression of ACE and ACE2 existed in normal cultured HK-2 ( NG group ). In comparison with NG group, the mRNA and protein expressions of ACE in HG group increased significantly ( P<0. 01 ), and the expression of ACE2 mRNA decreased significantly( P<0. 01 ). The level of Ang Ⅱ in HG group was significantly higher than in NG group( P<0. 05 ). The result show that high glucose may induce ACE expression and inhibit ACE2 expression, then promote synthesis of Ang Ⅱ in proximal tubular cells.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Endocrinology and Metabolism
Ano de publicação:
2011
Tipo de documento:
Artigo
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