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Study of central venous oxygen saturation used in transfusion of hemorrhagic shock rabbits / 中国医师杂志
Journal of Chinese Physician ; (12): 10-13, 2011.
Article em Zh | WPRIM | ID: wpr-424806
Biblioteca responsável: WPRO
ABSTRACT
ObjectiveTo study central venous oxygen saturation (ScyO2) in controlled hemorrhagic shock rabbits resuscitation process as a transfusion trigger and traditional transfusion trigger of comparison.MethodsSelection New Zealand pure line of rabbit 32 only,simple randonly divided into 4 groups,groups A and B for the observation group,groups C and D as control group,groups of eight only.A,B,C,D four groups respectively by ScvO2 ≤70%,ScvO2 ≤75%,hemoglobin (Hb)≥8g/dl,blood loss for the whole blood volume≥30% as transfusion trigger.From right femoral artery bloodletting 10 minute inside,made the MAP to about (40 ± 5 )mmHg,and maintained the blood pressure 60 minutes,established controlled hemorrhagic shock rabbits of animal model.And then started to resuscitate,with colloid and crystalloid infusion according to the proportion 1∶2,infusion rate of about 10 ~ 15ml/( kg · h),according to the blood pressure and heart rate,and proper adjustment according to the different requirements of each group conducted a blood transfusion.Monitoring based value,shock,shock treatment 30 minutes,60 minutes,120 minutes,180 minutes all time points,and various indexes of blood loss,blood transfusions,crystalloid and colloid fluid volume and so on.ResultsIn shock treatment observation group A late blood pressure,pH,BE,HCO3-,O2ER etc compared with the other three groups had obvious statistical differences ( P < 0.05 ),group B with C and D two groups at the same time points each monitoring were no significant differences ( P >0.05 ).The volume of transfusion group C was most,compared with the other three groups were significant difference ( P < 0.05 ),group D of blood transfusions than A,B two groups (P < 0.05 ),groups A and B infused colloid fluid,crystal fluid volume than groups C and D ( P < 0.05 ),each group blood lossed without significant difference.ConclusionScvO2 for controlled hemorrhagic shock rabbit resuscitation monitoring can guide controlled hemorrhagic shock rabbit of blood transfusions,according to ScvO2 ≤75% transfusion with traditional according to Hb or blood loss transfusion trigger comparison,can achieve the same resuscitation effect,and can more accurately and individualized guide transfusion,reduce unnecessary blood transfusions,save resources.
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Texto completo: 1 Índice: WPRIM Idioma: Zh Revista: Journal of Chinese Physician Ano de publicação: 2011 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Idioma: Zh Revista: Journal of Chinese Physician Ano de publicação: 2011 Tipo de documento: Article