Regulatory roles of microRNA in intestinal barrier dysfunction-associated diseases / 中华临床营养杂志

ABSTRACT

MicroRNAs (miRNAs) are a group of small (about 22 nucleotides),endogenous,noncoding RNAs that direct mRNA degradation and translational inhibition post-transcriptionally by binding to complementary sequences in the 3' untranslated regions of specific target mRNAs.miRNAs play multiple important roles in the intestinal epithelium,influencing a number of intestinal disease processes.This review summarizes the regulatory roles of miRNA in intestinal epithelial differentiation,architecture,membrane permeability,immunological function,and more importantly,the intestinal mucosal barrier dysfunction-associated diseases.