Regulatory roles of microRNA in intestinal barrier dysfunction-associated diseases / 中华临床营养杂志
Chinese Journal of Clinical Nutrition
; (6): 33-38, 2012.
Article
em Zh
| WPRIM
| ID: wpr-424862
Biblioteca responsável:
WPRO
ABSTRACT
MicroRNAs (miRNAs) are a group of small (about 22 nucleotides),endogenous,noncoding RNAs that direct mRNA degradation and translational inhibition post-transcriptionally by binding to complementary sequences in the 3' untranslated regions of specific target mRNAs.miRNAs play multiple important roles in the intestinal epithelium,influencing a number of intestinal disease processes.This review summarizes the regulatory roles of miRNA in intestinal epithelial differentiation,architecture,membrane permeability,immunological function,and more importantly,the intestinal mucosal barrier dysfunction-associated diseases.
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Índice:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Clinical Nutrition
Ano de publicação:
2012
Tipo de documento:
Article