Haemostatic disorders in children with acute leukemia

ABSTRACT

Hemorrhagic characters and hemostatic disorders have been investigated in 106 children with acute leukemia at the National Hospital of Pediatrics from September 1st 2002 to August 30th 2004. Results showed that bleeding signs on admission were found in 49.1%. With subcutaneous hemorrhages, petechie and bruise in skin were most common, and with mucosa hemorrhages, epistaxis and alveolar hemorrhage were more common but gastrointestinal mucosa hemorrhages and urinary hemorrhages were rare. Thrombocytopenia, prolonged APTT, hypofibrinogenemia, hypoprothrombinemia, and disseminated intravascular coagulation accounted for 91.5%, 47.2%, 23.6%, 18.9% and 2.8%, respectively. These disorders were often combined together. Hemorrhagic status related closely with thrombocytopenia. Prolonged APTT, decreased prothrombine rate, and hypofibrinogenemia were contributed to increase of hemorrhagic rate.