Helicobacter pylori infection in immediate relatives of patients with gastric cancer / 中华全科医师杂志

ABSTRACT

Objective To investigate the Helicobacter pylori (Hp) infection in the immediate relatives of patients with gastric cancer.Methods One hundred and eighty two immediate relatives of 86patients with gastric cancer and 126 age and sex-matched immediate relatives of 46 dyspeptic patients were enrolled in the study from March 2010 to March 2011.C14 or C13 urea breath tests were performed and for those with Hp-positive results serological typing was further performed.Results One hundred and forty two out of 182 immediate relatives of gastric cancer patients were Hp positive with a Hp infection rate of 78％,which was significantly higher than that of immediate relatives of dyspeptic patients ( 78.0％ vs 47.6％,x2 =30.5,P ＜ 0.05,P =0.006 ).The average age of former was significantly higher than that of latter (46 ±6 y vs 38 ± 6 y; t =13.34,P ＜ 0.05).The rate of serological type Hp-1 in immediate relatives of cancer patients was significantly higher than that of those of dyspeptic patients (68.3％ vs 38.3％,x2 =14.28,P ＜0.05 ).The infection rate of children,both parents of whom were infected with Hp and only one parent infected with Hp (52.8％,43.2％,respectively ) was higher than that of children whose parents were not infected with Hp ( 13.3％ ) ( x2 =6.80,P ＜ 0.01 and x2 =4.35,P ＜ 0.05 ).Conclusions The Hp infection rate is high in immediate familial members of gastric cancer patients and the predominant serological type of Hp is Hp-1.