The clinical comparattve study of warfarin and aspirin in anticoagulant therapy of elderly patients with paroxysmal atrial fibrillation / 中国医师进修杂志

ABSTRACT

ObjectiveTo observe and investigate the clinical effect and security of warfarin and aspirin in anticoagulant therapy of elderly patients with paroxysmal atrial fibrillation.MethodsOne hundred and ninety-seven elderly patients with paroxysmal atrial fibrillation were chosen and divided by random digits table method into two groupscontrol group (99 patients) with aspirin oral treatment;experimental group (98 patients) with warfarin oral treatment,the dose was adjusted according to the international normalized ratio (INR).The incidence of thrombosis embolism and adverse reactions of two groups were compared after 1-2 years following up.ResultsThe incidences of thrombosis embolism in control group [ 12.1％ ( 12/99 ) ] and experimental group [ 2.0％ ( 2/98 ) ] had significant difference ( P ＜ 0.05 ).There was no significant difference in the incidence of bleeding between control group[ 2.0％ (2/99)] andexperimental group [ 3.1％ (3/98) ] (P ＞ 0.05 ).The incidence of gastrointestinal reaction and allergic reaction of control group was 17.2％ ( 17/99 ),while the incidence of experimental group was 4.1％ ( 4/98 ),there was statistical difference (P ＜ 0.05 ).ConclusionsWith strictly control of INR in the range between 2.0 and 3.0,warfarin anticoagulant treatment for elderly patients with paroxysmal atrial fibrillation obtains definite clinical efficacy and fewer adverse reactions.It is worthy of clinical expansion and application.