Endothelial microparticles and the diseases of central nervous system / 国际儿科学杂志

ABSTRACT

Endothelial microparticles(EMPs) are microvesicles released from the membrane of activated,injured or apoptotic endothelial cells.It is important to discriminate EMPs from apoptotic bodies and exosomes.Endothelial microparticles contain protein,lipid,mRNA,microRNA and adhesion molecule.By now,the mechanisms that lead to the formation of EMPs are not completely elucidated,probably including loss of membrane phospholipid asymmetry and cytoskeleton reorganization.The connection between EMPs and central nervous system disease are getting more attracted.At different stages of diseases,such as ischemic stroke,hemorrhage stroke,macrovascular complications in type 2 diabetes mellitus,cerebral malaria,multiple sclerosis and traumatic brain injury,the level of EMPs in circulation or cerebral spinal fluid would change differently.It might be a biomarker to understand the mechanism,determine the severity and prognosis,and also the focus to diagnose and treat the central nervous system diseases.