Clinical study of bruceolic oil emulsion combined GP program in treatment of advanced nonsmall-cell lung cancer / 中国医师进修杂志

ABSTRACT

ObjectiveTo evaluate the clinical efficacy,untoward reaction of bruceolic oil emulsion combined GP program in treatment of advanced non-small-cell lung cancer(NSCLC).MethodsOne hundred and thirty-six patients with NSCLC were divided into observation group and control group with 68 cases each by random digits table,the two groups were received GP program,the observation group added bruceolic oil emulsion( 1 time a day).The effective rate and untoward reaction between two groups were compared.ResultsThe objective effective rates of observation group and control group were 32.4％(22/68)and 17.6％( 12/68 ),the subjective effective rates of observation group and control group were 52.9％(36/68 )and 32.4％ (22/68),there were significant differences between two groups(P ＜0.05).There was no significant difference in CD3+,CD4+,CD8+,CD56+ between two groups before treatment (P＞ 0.05 ).CD3+,CD4+,CD8+,CD56+ in observation group were better than those in control group after treatment(0.552 ± 0.072 vs.0.468 ± 0.080,0.368 ± 0.062 vs.0.288 ± 0.061,0.268 ± 0.052 vs.0.212 ± 0.044,0.226 ± 0.044 vs.0.168 ±0.042),there were significant differences between two groups (P ＜ 0.05).There was no statistical difference in Ⅲ+ Ⅳ degree untoward reaction between two groups(P ＞ 0.05).ConclusionBetter therapeutic efficacy and less untoward reaction are expected by combined bruceolic oil emulsion with GP program in treatment of advanced NSCLC.