Clinical observation of transcatheter arterial chemoembolization combined with argon-helium cryoablation on 35 patients with advanced unresectable primary hepatocellular carcinoma / 肿瘤研究与临床

ABSTRACT

ObjectiveTo evaluate the efficacy and safety of transcatheter arterial chemoembolization combined with argon-helium cryoablation on patients with advanced unresectable primary hepatocellular carcinoma. MethodsTranscatheter arterial chemoembolization was performed in 35 patients with primary hepatocellular carcinoma,then argon-helium cryoablation was done after 2-3 weeks.The second transcatheter arterial chemoembolization treatment was performed 1-2 week after argon-helium cryoablation.The after treatment response was evaluated and the toxicity was observed.RusultsThirty-five patients were evaluated.Complete response was observed in 7 patients,partial response in 21 patients,stable disease in 4 patients and progressive disease in 3 patients. Overall response rate was 80.00 ％(2g/35), and disease control rate was 91.43 ％(32/35). Patients' median PFS was 8.9 months, median OS was 16.3 months. ConclusionThe therapeutic effect of transcatheter arterial chemoembolization combined with argon-helium cryoablation is good in treating advanced unresectable primary hepatocellular carcinoma.