The study of the relationship between influenza virus infection and the dysfunction of vascular smooth muscle cells / 中华微生物学和免疫学杂志
Chinese Journal of Microbiology and Immunology
;
(12): 841-844, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-429322
ABSTRACT
Objective To research the influenza virus infection on rat vascular smooth cells number,proliferation,apoptosis,the amount of IL-6,sFas,platelet-derived growth factor(PDGF) and the mechanism of atherosclerosis.Methods Flow cytometry,enzyme-linked immunosorbent assay and cell count experiments were used to detect these indicators at 0 h,6 h,12 h,24 h,48 h.Results After influenza virus infected at 0 h,proliferation,apoptosis condition were 10.39%,0.44%,respectively; at 6 h,proliferation,apoptosis respectively increased to 12.68%,0.73% ; proliferation reached the peak at 12 h (18.01%),instead apoptosis decreased to 0.14% ; at 24 h,proliferation decreased to 12.89% and apoptosis markedly increased to 1.09% ; at 48 h,proliferation further reduced to 7.07% and apoptosis reached the peak(4.61%).The number of cells and the cytokine secretion were statistically significant to control group (P<0.05).Conclusion Influenza virus infection might lead to change of cell proliferation and apoptosis and involve the atherosclerosis form and development,and cytokines played an important role in them.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Microbiology and Immunology
Ano de publicação:
2012
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS