Microglia and white matter injury in preterm infants / 国际儿科学杂志

ABSTRACT

Periventricular leukomalacia in premature infants is the most common brain injury.It often results in spastic cerebral palsy,cognitive and behavioral abnormalities and other sequelae.The microglia is the primary immune response cell in brain,and it plays an important role in balancing mechanism for the defense response and brain injury.The suppression of its activated reaction can reduce the cytotoxic effect and pathological damage in the early phase.