CD40-CD40 ligand in pediatric disease / 国际儿科学杂志

ABSTRACT

CD40-CD40 ligand (CD40-CD40L) cross-linking,an important cell signaling transduction pathway in immune response,is involved in the regulation of cellular and humoral immune.CD40-CD40L signaling pathway abnormalities can lead to immune system disorders and incur immune pathological reaction.A variety of common pediatric diseases,such as immunodeficiency diseases,inflammatory diseases and autoimmune diseases,are associated with CD40-CD40L signaling transduction pathway abnormalities.The relationship between CD40-CD40L and the above-mentioned diseases is of clinical significance.