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Effect of metformin on proliferation and related genes expression of human osteoblast MG63 under high glucose / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism ; (12): 972-974, 2012.
Artigo em Chinês | WPRIM | ID: wpr-430358
ABSTRACT
The proliferation of MG63 cells under high glucose intervened with metformin was measured by CCK-8 assay.The activity of intracellular alkaline phosphatase (ALP) was detected by SFBC assay.The expression of related genes was detected by RT-PCR.Metformin promoted the proliferation of MG63 cells (P<0.01),the activity of ALP was increased (P<0.05).The expressions of collagen Ⅰ and osteocalcin were up-regulated while the expressions of matrix metalloproteinase (MMP)-1,MMP-2,MMP-3,and MMP-8 were down-regulated (P<0.05).The results indicate that metformin may protect osteoblast,via promoting osteoblast proliferation,differentiation and mineralization,as well as by inhibiting degradation of osteoblast extracellular collagen matrix.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Endocrinology and Metabolism Ano de publicação: 2012 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Endocrinology and Metabolism Ano de publicação: 2012 Tipo de documento: Artigo