Effect of cigarette smoking on platelet activation in elderly patients with acute coronary syndrome / 中华全科医师杂志
Chinese Journal of General Practitioners
;
(6): 202-204, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-430408
ABSTRACT
Fifty six elderly patients with acute coronary syndrome (ACS) were divided into nonsmoking group (n =30) and smoking group (n =26).All patients received aspirin 100 mg/d + Clopidogrel 75 mg/d for 14 d.The expression of glycoprotein Ⅱ b/Ⅲa and P-Selectin on the surface of platelets in both groups were assessed with flow cytometry (FCM).The positive expression rates of GP Ⅱ b/Ⅲ a and P-Selectin before treatment were (67.86 ± 12.14)%,(70.37 ± 10.15)% in non-smoking group and (79.47 ± 11.62) %,(81.26 ± 9.74) % in smoking group.The positive expression rates of GP Ⅱ b/Ⅲ a and P-Selectin after treatment were significantly decreased to (50.18 ± 8.72) %,(49.36 ± 11.43) % in nonsmoking group and to (61.15±9.29)%,(57.52±10.81)% in smoking group(P<0.01).Also the degree of decreasing expression rates of GP Ⅱ b/Ⅲ a and P-Selectin was nore markedly in non-smoking group than that in smoking group (P < 0.05).The results indicate that expressions of GP Ⅱ b/Ⅲ a and P-Selectin on the surface of platelets are increased in the elderly smoker patients with ACS,and smoking may decrease the effect of anti-platelet agents.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of General Practitioners
Ano de publicação:
2013
Tipo de documento:
Artigo
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