Effects of different types of extracorporeal circuits on concentrations of sufentanil in priming solution / 中华麻醉学杂志

ABSTRACT

Objective To evaluate the effects of different types of extracorporeal circuits (ECCs) on the concentrations of sufentanil in the priming solution.Methods The experiment was performed in three groups (n =6 each).Two types of ECCs were usedXi-jing type 90 oxygenator (group Ⅰ) and Termo Capiox SX18 membrane oxygenator (group Ⅱ),while in control group (group Ⅲ) a glass container was used.The ECC and glass container were filled with the priming solution (succinylated gelatin 1000 ml + lactated Ringer' s solution 1000 ml).Sufentanil 15 μg (concentration 7.5 ng/ml) was then added to the priming solution.The priming solution was circulated in the closed ECC or stirred in the glass container.The concentration of sufentanil in the priming solution was determined by gas chromatography-mass spectrometry at 3,5,10,20,30,40,50,60,70,80 and 90 min after addition of sufentanil.Results The concentration of sufentanil in the priming solution was significantly decreased at the different time points in groups Ⅰ and Ⅱ as compared with group Ⅲ (P ＜ 0.05).The concentration of sufentanil in the priming solution was significantly lower at each time point in group Ⅰ than in group Ⅱ (P ＜0.05).Conclusion Both the two types of ECCs can absorb sufentanil and the adsorption of Xi-jing type 90 oxygenator is stronger than that of Termo Capiox SX18 membrane oxygenator.