Serum level changes of leptin and 5-hydroxytrytamine in patients with premature ejaculation before and after hydrochloride sertraline treatment / 中华全科医师杂志

ABSTRACT

A total of 71 patients with premature ejaculation (PE) received hydrochloride sertraline treatment for 8 weeks and their serum levels of leptin and 5-hydroxytrytamine (5-HT) were determined.Their ejaculation functions were assessed with intravaginal ejaculation latency time (IELT) and Chinese index of premature ejaculation (CIPE-5) value.The study was compared with 64 normal males as control.The baseline level of leptin in the trial group was obviously higher than the controls (P ＜ 0.05) while the level of 5-HT in the trial group far lower than the controls (P ＜ 0.05).At 8 weeks,the level of leptin dropped while the level of 5-HT rose in the trial group after treatment.Therefore a high serum level of leptin and a low serum level of 5-HT may become biological indicators for PE.