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Research on induced apoptosis of recombinant human adenovirus-p53 injection in patients with oral leukoplakia / 肿瘤研究与临床
Cancer Research and Clinic ; (6): 107-109, 2013.
Artigo em Chinês | WPRIM | ID: wpr-431466
ABSTRACT
Objective To probe the biological effect of multiple intraepithelial injections of recombinant adenovirus-p53(rAd-p53)on inducing the apoptosis in patients with dysplastic oral leukoplakia.Methods 18 patients clinically and histopathologically diagnosed as dysplastic oral leukoplakia were recruited for this study.Intraepithelial injections of rAd-p53 were administered.Immunohistochemistry was used to examine the protein expression of p53 and bcl-2.TUNEL was performed to detect apoptotic cells.Results In the post-treatment patients,p53 protein expression were significantly enhanced(100 %,18/18),yet bcl-2 protein presented low expression(17 %,3/18).Statistical analysis revealed the expression of p53 protein had a negative correlation with that of bcl-2 protein(r =-0.837,P < 0.01).15 post-treatment samples (83 %)were detected obvious apoptotic cells,especially in the samples that were strong p53-positive(r =0.684,P < 0.01).Conclusion Intraepithelial injections of rAd-p53 can induce apoptosis for patients with dysplastic oral leukoplakia.It may be a promising treatment for oral leukoplakia.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Cancer Research and Clinic Ano de publicação: 2013 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Cancer Research and Clinic Ano de publicação: 2013 Tipo de documento: Artigo