The curative effect and safety of olmesartan cilexetil in patients with mild to moderate primary hypertension / 中国基层医药

ABSTRACT

Objective To study the curative effect and the safety of olmesartan medoxomil in patients with mild to moderate primary hypertension.Methods 121 patients with mild to moderate essential hypertension were randomized into two groupsolmesartan group (n =60),received olmesartan 20mg/day and valsartan group (n =61),received valsartan 8mg/day.Before and after the 8 weeks treatment,blood pressurem,ECG,blood and urinary laboratory exanination were observed in EH cases.Results After 8 weeks,Compared to valsartan group,the olmesartan group showed significantly erduction in both systolic blood pressure [(120.54 ± 12.78) mmrn Hg(128.32 ± 10.01) mm Hg]and diastolic blood pressure[(73.27 ± 4.01) mm Hg(79.65 ± 4.89) mm Hg].In terms of the 24 h ABPM,olmesartan monotherapy exhibited a sustained 24h BP reduction profile with the trough-to-peak ratios more than 50％.The side effect in olmesartan group was 2 cases,and 5 cases in valsartan group.Conclusion Candesartan cilexetil can be used in the treatment of patients with mild and moderate essential hypertension effectively and safely.