Expressions of phosphorylated AKT and phosphorylated EGFR in non-small cell lung cancer and their significance / 肿瘤
Tumor
;
(12): 328-333, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-433348
ABSTRACT
Objective:
To evaluate the expressions of phosphorylated epidermal growth factor receptor (p-EGFR) and its downstream molecule phosphorylated AKT(p-AKT) in non-small cell lung cancer (NSCLC)and their significance.Methods:
The immunhistochemistry was used to detect the expressions of p-AKT and p-EGFR proteins in 95 cases of NSCLC tissues. The relationship between the p-AKT and p-EGFR and between their expression and prognosis were also evaluated.Results:
The positive rate of p-EGFR was 57.89% (55/95) and was related with age, gender and histological type (P=0.008,P=0.003,P=0.009). The positivity of p-EGFR was higher in young group (33/46), female group (24/30), and adenocarcinoma group (35/52). The positive rate of p-AKT was 66.32% (63/95) and was related with differentiation, lymph node metastasis and tumor size (P=0.036,P=0.047,P=0.017,res-pectively). The positivity of p-AKT was higher in low differentiation group (20/23), lymph node metastasis group (29/37), and tumor diameter ≤3 cm group (36/46). Univariate analysis showed that the expressions of p-AKT and p-EGFR were not associated with prognosis (P=0.854, P=0.729). Multivariate analysis showed that neither p-AKT nor p-EGFR was correlated with the patients' survival time (P=0.497, P=0.731). The p-AKT was positively correlated to the p-EGFR(r=0.204, P=0.047).Conclusion:
The expressions of p-AKT and p-EGFR had no impact on the prognosis of NSCLC. They can not serve as prognostic indicators for NSCLC.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
Tumor
Ano de publicação:
2010
Tipo de documento:
Artigo
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