Correlated study for the levels of NO,NOS and PRL with neonatal h ypoxic-ischemia en cephalopathy / 临床儿科杂志

ABSTRACT

To explore th e role of nitric oxide(NO), nitric oxide synthetase (NOS)and prolactin (PRL) in the pathogenesis,progress and prognosis of neonatal hypoxic-ischemia encephalop athy (HIE),plasma NO, NOS and serum PRL were determined by radioimmunoassay(RIA) and colorimetry in 68 newbom infants with HIE and 30 normal control neonates, r espectively. The results showed that the levels of NO, NOS and PRL were signific antly higher in all neonates with HIE than that in the control group (P＜0.05).There were in particular more higher levels of NO,NOS an d PRL in infants with either moderate or severe HIE(P＜0 .01). It was noticed that the level of PRL was much higher in HIE infants with seizures than that in HIE infants without seizures. There was a positive relati onship between the levels of PRL and the duration of seizure attack( P＜0.01). It is suggested that the levels of NO, NOS and PRL is ass ociated with HIE.The determination of these parameters will be valuable clinical ly for the diagnosis, judgement of prognosis and estimation of seizure attack in newborn infants with HIE.