Evaluation on efficiency of low molecular weight heparin as a single bolus dose with reused dialyzers / 安徽医科大学学报
Acta Universitatis Medicinalis Anhui
; (6): 121-123, 2001.
Article
em Zh
| WPRIM
| ID: wpr-433933
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WPRO
ABSTRACT
Objective To evaluate the efficiency of low molecular weight heparin(LMWH, fraxiparine) given as a single predialysis bolus injection with reused dialyzers in comparison with standard heparin(SH) administered with a continuous infusion. Methods 30 hemodialysis patients were studied in a radomized crossover fashion. Dialyzers fibrer bundle volumes(FBV), predialysis hemocrit and 2 h clearance of urea, creatinine were observed in the first, the fourth dialysis. The plasma heparin activities(anti-Fxa levels) were measured by the chromogenic substrate assay in 0 h, 2 h, 4 h of dialysis. Results Significant increase (P0.05); in addition, the plasma heparin activity(anti-Fxa levels) were comparable in both groups after 2 h of dialysis, however, they were significantly higher after 4 h in the LMWH than those in the SH group (P<0.05). Conclusion LMWH as a single bolus dose can prevent decrease in dialyzer clearance. It is clinically worthy of further popularity.
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Índice:
WPRIM
Idioma:
Zh
Revista:
Acta Universitatis Medicinalis Anhui
Ano de publicação:
2001
Tipo de documento:
Article