Gene expression spectra in human hepatoma SMMC-7721 cells treated with gambogic acid / 中国药科大学学报

ABSTRACT

Aim: To investigate gene expression spectra in human hepatoma cell line SMMC-7721 treated with gambogic acid (GA).Methods:Human cDNA microarray and RT-PCR technology were used to detect the changes in gene expression. Results: 31 genes in groups exposed to gambogic acid for 24 h and 56 genes for 48 h group were expessed differentially in comparison to the control group. ConclusiorThe antitumor mechanism of GA might focus on apoptosis,metastasis as well as interfering with the cell cycle.