The relationship between the expression of EGFR NF-κB and radiosensitivity in human nasopharyngeal carcinoma / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
; (24): 678-681, 2009.
Article
em Zh
| WPRIM
| ID: wpr-434249
Biblioteca responsável:
WPRO
ABSTRACT
Objective:To detect the expression of EGFR and NF-ΚB and the relationship between the two fac-tors and radiosensitivity in human nasopharyngeal carcinoma. Methods The expression of EGFR and NF-ΚB were detected with immunohistochemical staining SP methods in forty-one patients. The radiotherapy effect was assessed by follow up visit and clinical judgement. All of the forty-one patients were divided into three groups: the complete response group,the partial response(or the stable disease)group and the progressive disease group. Result:The ex-pression of EGFR and NF-ΚB were detected in human nasophaTyngeal carcinoma tissues, which were not in normal ones. EGFR and NF-ΚB were significant difference of the radiosensitivity in nasopharyngeal carcinoma tissues (P0. 05). The two factors'expression had negative correlation with radiosensitivity. Conclusion: EGFR and NF-ΚB, as important tar-gets, could predict the radiosensitivity of NPC, which could be helpful for targeting treatment and promote the effect of radiotherapy of NPC.
Texto completo:
1
Índice:
WPRIM
Tipo de estudo:
Prognostic_studies
Idioma:
Zh
Revista:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Ano de publicação:
2009
Tipo de documento:
Article