Correlated Study of CRP、IL-12 and Insulin resistance in Gestational Diabetes Mellitus / 中国医师进修杂志
Chinese Journal of Postgraduates of Medicine
; (36): 22-24, 2012.
Article
em Zh
| WPRIM
| ID: wpr-434476
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WPRO
ABSTRACT
Objective to investigate the relationship between CRP,IL-12 and gestational diabetes mellitus.Methods Fifty normal pregnant women (NGT group) and forty with GDM (GDM group) were enrolled in the study.The serum IL-12、fasting blood sugar、CRP were mesured respectively.Results GDM fasting blood glucose,fasting insulin,insulin resistance index (IRI),CRP,IL-12 were higher than those in the control group [(4.95 ± 0.76 vs 4.57 ± 0.58) mmol/L,(13.65 ± 1.74 vs 8.78 ± 1.65) uIU/ml,(2.91 ± 1.05vs 1.72 ± 0.87),(5.56 ± 1.24 vs 3.25 ± 1.13) mg/L,(71.47 ± 4.35 vs 56.03 ± 4.06) PG,/ml,P < 0.05),the results of single factor analysis of CRP showed a positive correlation with IRI (r =0.865,P < 0.05),IL-12 was positively correlated with IRI (r =0.913,P < 0.05).Conclusions Our study show inflammatory cytokins take part in the genesis of gestational diabetes.Serum levels of IL-12 and is one factor in pathogensis of GDM.
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WPRIM
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Zh
Revista:
Chinese Journal of Postgraduates of Medicine
Ano de publicação:
2012
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Article