Prevention of chronic graft-versus-host disease by stimulation with glucocorticoid-induced TNF receptor
Experimental & Molecular Medicine
;
: 94-99, 2006.
Artigo
em Inglês
| WPRIM
| ID: wpr-43450
ABSTRACT
GITR (glucocorticoid-induced TNF receptor) is a recently identified member of the TNF receptor superfamily. The receptor is preferentially expressed on CD4+CD25+ regulatory T cells and GITR signals break the suppressive activity of the subset. In this study, we wanted to reveal the in vivo function of GITR in chronic graft-versus-host disease (cGVHD), a lupus-like autoimmune disease. A single injection of anti-GITR monoclonal antibody (DTA-1) was effective in blocking the progression of cGVHD in the parent-into-F1 model. Treatment of DTA-1 significantly decreased levels of IgG1 anti-DNA autoantibody, inhibited glomerulonephritis, and increased survival. The DTA-1-mediated inhibition of autoantibody production correlated with deletion of B cells and could occur independently of CD4+CD25+ regulatory T cells. Our results indicate that anti-GITR monoclonal antibody may be used as a potential immunotherapeutic agent for preventing cGVHD.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Transplante Homólogo
/
Ensaio de Imunoadsorção Enzimática
/
Estudo Comparativo
/
Linfócitos B
/
Linfócitos T CD4-Positivos
/
Fluoresceína-5-Isotiocianato
/
Receptores do Fator de Necrose Tumoral
/
Microscopia Confocal
/
Técnica Indireta de Fluorescência para Anticorpo
/
Citometria de Fluxo
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Experimental & Molecular Medicine
Ano de publicação:
2006
Tipo de documento:
Artigo
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