The clinical efficacy and safety of indapamide combined with metoprolol in the treatment of hypertension patients with chronic heart failure / 中国基层医药

ABSTRACT

Objective To observe the effect and safety of metoprolol combined with indapamide in the treatment of hypertension patients with chronic heart failure (CHF).Methods 78 hypertension patients with CHF were given indapamide 2.5mg/d,metoprolol 6.25mg/d,1time/d,based on conventional anti-heart failure treatment,the double dose was given two weeks later.Then the dose was adjusted according to the patients' condition and the individual response.Blood pressure,heart rate and cardiac function were observed.Results Compared with before treatment,systolic blood pressure [(142.6 ±5.1)mm Hg vs (178.0 ±7.5) mm Hg],diastolic blood pressure[(91.3 ± 3.6)mm Hg vs (109.5 ± 4.2) mm Hg],heart rate [(76 ± 9) times/min vs (117 ± 11) times/min],LVEDVI [(133 ± 14)ml/m2 vs (164 ±21) ml/m2] and the LVESVI[(92 ± 10)ml/m2 vs (118 ± 17)ml/m2] were significantly reduced after treatment,and the differences were statistically significant (all P ＜ 0.05).Cardiac function was significantly improved,the total effective rate was 93.6％.Conclusion Metoprolol and indapamide combination therapy for hypertension patients with CHF has good efficacy,it is safe and worthy of clinical application.