Efficacy and safety of butyiphthalide and nimodipine in the treatment of vascular dementia / 中国综合临床

ABSTRACT

Objective To observe the efficacy and safety of butyiphthalide and nimodipine in the treatment of vascular dementia (VAD).Methods Eighty cases with VAD were randomly divided into the treatment group (40 cases) and the control group (40 cases).The control group were given 30 mg nimodipine for three times a day ;The treatment group was given additionally three times a day of 0.2 g butyiphthalide for 12 consecutive weeks.The Mini-Mental State Examination (MMSE),Clinical Dementia Rating (CDR),and Activities of Daily Living (ADL) scores were used for the assessment of cognitive function.The assessments were done before and after treatment.The adverse effects were also recorded.Results In the treatment and the control groups,the MMSE,CDR and ADL scores (MMSE23.17 ± 1.89,19.43 ± 2.04; CDR1.06 ± 0.11,1.21 ±0.50;ADL40.11 ±5.10,41.22 ±4.80) after treatment were significantly improved than those (MMSE16.54 ± 1.98,16.28 ± 2.11 ; CDR1.78 ± 0.25,1.75 ± 0.31 ; ADL47.45 ± 5.22,46.75 ± 5.31) (MMSEt =2.42,P ＜0.05,t =2.34,P ＜0.05 ;CDRt =1.67,P ＜ 0.05,t =1.54,P ＜0.05 ;ADLt =6.73,P ＜0.05,t =5.24,P ＜ 0.05) before treatment.After 12 weeks of treatment,the MMSE,CDR and ADL scores in the butyiphthalide group were significantly improved than that in the control group (t =1.85,1.84,5.91,respectively; P ＜ 0.05).No serious adverse events were recorded during the treatment.Conclusion Butyiphthalide and nimodipine can prominently improve,better than nimodipine alone,the cognitive function of patients with vascular dementia.Moreover,its security and tolerability are good.