BDNF and TrkB may be new hope for treatment of tumor / 国际外科学杂志

ABSTRACT

Brain-derived neurotrophic factor is the ligands of tyrosine kinase receptor B,for the binding of brain-derived neurotrophic factor to tyrosine kinase receptor B receptor,signal transmitted to the nucleus,resulting in a variety of biological effects.Lots of researchs had found that brain-derived neurotrophic factor and tyrosine kinase receptor B expression in malignant tumors more than non-cancerous adjacent tissue and normal tissue,and their effect can promote tumor blood vessel formation,suppress of cell anoikis,promote tumor growth,differentiation and metastasis.The relationship of brain-derived neurotrophic factor and tyrosine kinase receptor B provide a new therapeutic strategy for clinical treatment.From the current basic and clinical research,this treatment strategy has great prospect.