Progress of pathogenesis and potential future implications of refractory epilepsy / 临床儿科杂志
Journal of Clinical Pediatrics
;
(12): 1001-1004, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-435397
ABSTRACT
Epilepsy is a common neurological disorder of children. Research in recent years on the mechanism of refractable epilepsy has made some breakthrough. Four concepts have been put forward to explain the development of pharmacoresistance. The transporter hypothesis have become the focus, which contends that the expression or function of multidrug transporters in the brain is augmented, leading to impaired access of antiepileptic drugs to central nervous system targets. An emerging understanding of these underlying molecular and cellular mechanisms is likely to provide important impetus for the development of new pharmacological treatment strategies and clinical test facility.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo de etiologia
Idioma:
Chinês
Revista:
Journal of Clinical Pediatrics
Ano de publicação:
2009
Tipo de documento:
Artigo
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