Studies on inhibitive effect of low-voltage electrochemotherapy on head and neck cancer-bearing nude mice / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 991-994, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-435430
ABSTRACT
Objective:
To analyse the therapic effect of low-voltage electrochemotherapy (EP) on the head and neck cancer.Method:
YCU-N861 human head and neck cancer cells were subcutaneously inoculated in the neck of nude mice to establish tumor-bearing models. Then the mice were treated with bleomycin(BLM, 20 μg per mouse), accompanied with electric stimulation(50 V or 100 V).Result:
BLM treatment applied with EP can significantly inhibite the proliferation of tumor cells than BLM or EP treatment seperately(P<0.01) . The tumor volume, the mitotic index (MI) and the labeling index (LI) of Ki67 in BLM+EP group were all obviously decreased than BLM group, EP group and control group (P<0.01).Conclusion:
Low-voltage electrochemotherapy can offer promising mothod in the local treatment of head and neck cancer.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Ano de publicação:
2009
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS