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The Effect of Preoperative Oral Application of Bovine Colostrum on Endotoxemia and TNF-alpha in Abdominal Surgery
Journal of the Korean Surgical Society ; : 462-469, 2006.
Artigo em Coreano | WPRIM | ID: wpr-43556
ABSTRACT

PURPOSE:

We conducted this study to assess the effect of oral application of bovine colostrum on the plasma endotoxin and TNF-alpha following the abdominal surgery.

METHODS:

46 patients who underwent the abdominal surgery were evenly enrolled in a prospective, randomized, double blind and placebo-controlled study. The patients were preoperatively managed by oral application of 20 g of a bovine colostrums or placebo (nonfat dried milk) per a day for 3 days. In both groups, endotoxin was sequentially determined pre-, intra- and postoperatively by a modified limulus amebocyte lysate test. TNF-alpha and CRP were also measured. The clinical course was followed and compared in both groups.

RESULTS:

The colostrum group showed significantly lower level of endotoxin and TNF-alpha compared to the placebo group. CRP did not differ in both groups. Clinical event did not occur in both group until the discharge. Colostrum group tends to have a lower incidence of fever and leukocytosis without statistic significance.

CONCLUSION:

Prophylactic preoperative oral application of bovine colostrum lower the plasma level of perioperative endotoxin and TNF-alpha. Further studies were needed for the relation of clinical effect and preoperative oral application of bovine colostrum.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Plasma / Incidência / Estudos Prospectivos / Fator de Necrose Tumoral alfa / Colostro / Endotoxemia / Febre / Caranguejos Ferradura / Leucocitose Tipo de estudo: Ensaio Clínico Controlado / Estudo de incidência / Estudo observacional / Estudo prognóstico Limite: Humanos Idioma: Coreano Revista: Journal of the Korean Surgical Society Ano de publicação: 2006 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Plasma / Incidência / Estudos Prospectivos / Fator de Necrose Tumoral alfa / Colostro / Endotoxemia / Febre / Caranguejos Ferradura / Leucocitose Tipo de estudo: Ensaio Clínico Controlado / Estudo de incidência / Estudo observacional / Estudo prognóstico Limite: Humanos Idioma: Coreano Revista: Journal of the Korean Surgical Society Ano de publicação: 2006 Tipo de documento: Artigo