The relationship between oxidative stress and urinary tract infection during pregnancy / 中国医师杂志

ABSTRACT

Objective To explore the relationship between oxidative stress and urinary tract infection (UTI) during pregnancy.Methods The urine superoxide dismutase (SOD),catalase (CAT) malondialdehyde (MDA) were measured in 188 pregnant women and 80 healthy women.Results UTI was observed in 39 of 188 pregnant women.The levels of CAT,SOD,and MDA were significantly increased in pregnant women compared to nonpregnant women [(CAT7.47 ± 0.56) U/ml vs (4.56 ± 0.36) U/ml,P＜0.01 ; SOD(11.62 ±0.96) U/ml vs (10.25 ±0.89) U/ml,P ＜0.01 ; MDA(2.46 ±0.22) nmol/mg vs (1.28 ± 0.11) nmol/mg,P ＜ 0.01].The activities of CAT and SOD,and the level of MDA were significantly increased from the first trimester to the third trimester in pregnancy(P ＜ 0.01).The activities of CAT in UTI group [(3.15 ± 0.49) U/ml were significantly lower that the non-UTI group (10.25 ± 0.89)U/ml] (P ＜ 0.01).The activities of SOD in the UTI goup [(4.38 ± 0.37) U/ml were significantly lower than the non-UTI group (13.52 ± 1.11)U/ml] (P ＜0.01).The level of MDA in UTI group [(2.58 ±0.24) nmol/mg] was significantly higher than the non-UTI [(2.43 ±0.21)nmol/mg] (P ＜ 0.01).The rate of UTI (20.74％) in the pregnancy was significantly higher than that in the nonpregnant women (10.00％) (P ＜ 0.05).Conclusions Oxidative stress may be the cause of UTI in pregnant women.