Immunohistochemical study on the expression of calcium binding proteins (calbindin-D28k, calretinin, and parvalbumin) in the cerebellum of the nNOS knock-out(-/-) mice / 대한해부학회지
Anatomy & Cell Biology
;
: 64-71, 2010.
Artigo
em Inglês
| WPRIM
| ID: wpr-43656
ABSTRACT
Nitric Oxide (NO) actively participates in the regulation of neuronal intracellular Ca2+ levels by modulating the activity of various channels and receptors. To test the possibility that modulation of Ca2+ buffer protein expression level by NO participates in this regulatory effect, we examined expression of calbindin-D28k, calretinin, and parvalbumin in the cerebellum of neuronal NO synthase knock-out (nNOS(-/-)) mice using immunohistochemistry. We observed that in the cerebellar cortex of the nNOS(-/-) mice, expression of calbindin-D28k and parvalbumin were significantly increased while expression of calretinin was significantly decreased. These results suggest another mechanism by which NO can participate in the regulation of Ca2+ homeostasis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Proteína G de Ligação ao Cálcio S100
/
Proteínas de Ligação ao Cálcio
/
Imuno-Histoquímica
/
Córtex Cerebelar
/
Cerebelo
/
Cálcio
/
Óxido Nítrico Sintase
/
Homeostase
/
Neurônios
/
Óxido Nítrico
Limite:
Animais
Idioma:
Inglês
Revista:
Anatomy & Cell Biology
Ano de publicação:
2010
Tipo de documento:
Artigo
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