Application of proteomics in radiation-related cancer research / 肿瘤研究与临床

ABSTRACT

Radiation-induced cancer is the most severe remote effect caused by radiation in human.Radiation-induced cancer includes leukemia,multiple myeloma,thyroid carcinoma,lung cancer,breast cancer,gastric cancer,and colon cancer.As protein is the executor of life activities,more and more research has been transfered from genomics to proteomics with the coming of post-genome era,and proteomics has became one of the hot research areas in life science.Proteomics is to study all expressed proteins' function encoded by genome sequences,and it provides a good way to study the composition and variation features in different stages and treatment conditions of cancer from the whole level.Therefore,proteomics has been widespreadly applicated in many fields of cancer research such as finding tumor markers,discovering molecular mechnism,early diagnosis,therapeutic efficacy assessment,cancer prevention and prognosis,etc.This article reviews the recent application of proteomics in some kinds of radiation-induced cancer.