The influence of amiodarone on serum hs-CRP and QTd in patients with ventricular arrhythmia of coronary heart disease / 中国基层医药

ABSTRACT

Objective To observe the influence of amiodarone on serum high-sensitivity C-reactive protein (hs-CRP) and QT dispersion (QTd) in patients with ventricular arrhythmia of coronary heart disease.Methods 92 patients with ventricular arrhythmia of coronary heart disease were randomly divided into the observation group(n =50 cases) and the control group (n =42 cases).The patients in the observation group were treated through the conventional treatment plus amiodarone,while the patients in the control group were treated through the conventional treatment plus metoprolol.They were treated for two weeks.Serum hs-CRP and QTd were detected before and after treatment.Results The total effective rate of the observation group was 94％ and that was 83％ in the control group.There was significant difference between two groups (x2 =4.790,P ＜ 0.05).After treatment,the serum hs-CRP and QTd were decreased(t =2.009,2.019,11.020,4.975,P ＜ 0.05),those in the observation group were significandy lower than in the control group(t =2.018,5.102,P ＜ 0.05).Conclusion Amiodarone can decrease serum hs-CRP and QTd in patients with ventricular arrhythmia of coronary heart disease and improve patients' condition.