Clinical efficacy and pharmacoeconomics of ilaprazole in the treatment of reflux esophagitis / 中国基层医药

ABSTRACT

Objective To analyze the clinical effects and pharmacoeconomics of ilaprazole in the treatment of reflux esophagitis.Methods 80 reflux esophagitis patients were selected as research subjects,who were divided into observation group and the control group,each group 40 cases according to the random number table.The observation group was given ilaprazole treatment,the dose for the 10mg/d;the control group received esomeprazole treatment,the dose for the 40mg/d.After 8 weeks of treatment,the clinical efficacy and cost of treatment of the two groups were compared.The ilaprazole clinical efficacy and pharmacoeconomics treatment of reflux esophagitis was explored.Results (1) After 8 weeks of treatment,symptom scores in patients of the observation group(0.7 ± 0.3)point,compared with before treatment(3.1 ± 0.8) point was significantly lower,the difference was statistically significant (t =16.7,P ＜0.01).The control group patients after symptom score(0.4 ±0.3) than before treatment(3.2 ±0.9) was also significantly reduced,the difference was statistically significant (t =18.6,P ＜0.01) ;there was no statistically significant in score after 8 weeks of treatment between the two groups(t =0.00,P ＞0.05).35 cases in the observation group had markedly effectiveness in 2cases,the total effective rate was 92.5％ ;36 cases in control group had markedly effectiveness in 2 cases,the total rate was 95％ ;efficiency of treatment of the two groups of patients was compared with that difference was not statistically significant(x2 =0.21,P ＞0.05).3) The analysis found that the observation group 34 cases were cured,improved in 2 cases,total effective rate was 90％ ;the control group,35 cases were cured,2 cases improved endoscopic efficacy in two groups of patients after 8 weeks of treatment,the total was 92.5％ ;4) There was no statistically significant difference in the efficiency of treatment of the two groups (x2 =0.15,P ＞0.05).The cost of treatment between the two groups was not statistically significant (t =0.99,P ＞ 0.05).Conclusion Ilaprazole has the similar clinical effect and cost with esomeprazole in the treatment of reflux esophagitis,and ilaprazole is an effective drug for treatment of reflux esophagitis.