DNA methylation and congenital heart disease pathogenesis / 国际儿科学杂志
International Journal of Pediatrics
;
(6): 370-374, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-437378
ABSTRACT
The roles that DNA methylation play in the congenital heart disease have recently begun to come to light.The abonormal DNA meghylation pattern on key regulation gne during heart development,such as T-box,CHD7,LINE1,methylenetrahydrofolate reductase,changed the expression of those gene,and increased the incidence of the congenital heart disease.The DNA methylation could be determined by sequencing,methylationsensitive PCR and combined bisulfate restriction anylysis.To study the DNA methylation will not only reveal the mechanism of congenital heart disease,but also provide a new strategy for clinical diagnosis and treatment.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo de etiologia
Idioma:
Chinês
Revista:
International Journal of Pediatrics
Ano de publicação:
2013
Tipo de documento:
Artigo
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