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The Efficacy and Safety of Tadalafil 5 mg Once Daily in the Treatment of Erectile Dysfunction After Robot-Assisted Laparoscopic Radical Prostatectomy: 1-Year Follow-up
Korean Journal of Urology ; : 112-119, 2014.
Artigo em Inglês | WPRIM | ID: wpr-43767
ABSTRACT

PURPOSE:

To evaluate the efficacy and safety of tadalafil 5 mg once daily use in the treatment of erectile dysfunction (ED) after robot-assisted laparoscopic radical prostatectomy (RALP). MATERIALS AND

METHODS:

The study retrospectively evaluated 92 patients who underwent RALP at Dong-A University Hospital. The patients were surveyed by use of the abridged five-item version of the International Index of Erectile Function (IIEF-5) questionnaire, which was self-administered before surgery and at 6 months and 1 year after surgery. The 92 patients were classified into the tadalafil group (n=47) and the non-tadalafil group (n=45). Each group was then classified depending on the nerve-sparing (NS) procedure used bilateral NS or unilateral NS.

RESULTS:

At 6 months, the total IIEF-5 scores of the tadalafil group and the non-tadalafil group were 10.0+/-3.4 and 7.0+/-4.0, respectively. At 1 year, the total IIEF-5 score in the tadalafil group was significantly greater than that in the non-tadalafil group (13.2+/-5.6 vs. 7.7+/-4.8, p<0.0001). Statistically significant improvements (p<0.05) were observed in the tadalafil group for all 5 domains of the IIEF-5 score, whereas in the non-tadalafil group there was no significant improvement in any of the domains at 1 year. The reported side effects were flushing (8.5%, n=4), headache (4.3%, n=2), and dizziness (2.1%, n=1).

CONCLUSIONS:

In ED patients after NS RALP, a once-daily dose of tadalafil 5 mg was well tolerated and significantly improved EF compared with that in the non-tadalafil group.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Prostatectomia / Robótica / Inquéritos e Questionários / Estudos Retrospectivos / Seguimentos / Tontura / Rubor / Cefaleia / Disfunção Erétil Tipo de estudo: Estudo observacional / Estudo prognóstico Limite: Humanos / Masculino Idioma: Inglês Revista: Korean Journal of Urology Ano de publicação: 2014 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Prostatectomia / Robótica / Inquéritos e Questionários / Estudos Retrospectivos / Seguimentos / Tontura / Rubor / Cefaleia / Disfunção Erétil Tipo de estudo: Estudo observacional / Estudo prognóstico Limite: Humanos / Masculino Idioma: Inglês Revista: Korean Journal of Urology Ano de publicação: 2014 Tipo de documento: Artigo