The expresssion of p53 and p27 in lung cancer and its clinical significance / 中国医师进修杂志

ABSTRACT

Objective To investigate the expression and clinical significance of p53 and p27 in lung cancer.Methods From December 2011 to December 2012,100 cases of patients with lung cancer were enrolled in this study.Another 40 person without lung cancer were collected as normal control.The protein expression of p53 and p27 was detected by immunohistochemistry.Results The positive rate of p53 in normal control was lower than that in lung cancer patients [27.5％ (11/40) vs.66.0％ (66/100)] (P ＜ 0.05).The positive rate of p27 in normal control group was higher than that in lung cancer group [87.5％(35/40) vs.41.0％(41/100)] (P ＜ 0.05).The expression of p53 and p27 had no relationship with the gander and rumor tissue type in lung cancer patients (P ＞ 0.05),but had relationship with the clinical pathologic stage (P ＜0.05).Spearman correlation analysis showed that the expression of p53 and p27 protein in lung cancer tissue had significantly negative correlation (r =-0.516,P＜ 0.05).Conclusion The abnormal expression of p53 and p27 may be involved in the occurrence and development of lung cancer,and their joint detection may be used as the new molecular marker in the diagnosis and prognosis assessment of lung cancer.