Influence of propofol and isoflurane on insulin resistance and proinflammatory cytokines / 中国基层医药

ABSTRACT

Objective To investigate the influence of propofol and isoflurane on insulin resistance and proinflammatory cytokines.Methods 42 patients underwent abdominal surgery were randomly divided into group A and group B.All cases were given conventional endotracheal intubation anesthesia.Group A (21 cases) was given propofol anesthesia,group B (21 cases) was given isoflurane.The levels of glucose (Glu),insulin (IN),interleukin-6 (IL-6) and tumor necrosis factor alpha(TNF) were detected before anesthesia,2h after anesthesia and postoperative 24h.Insulin sensitive index(ISI) and insulin resistance index(IRI) were calculated.All data were analyzed.Results 2h after anesthesia,Glu level of group B was obviously increased compared with before anesthesia(P ＜ 0.05).But it of group A was slightly increased (P ＞ 0.05).Postoperative 24h,Glu level of the two groups was obviously increased compared with before anesthesia (P ＜ 0.05).2h after anesthesia and postoperative 24h,IN,IRI,IL-6 and TNFαdevels of the two groups were obviously higher than before anesthesia(P ＜ 0.05).ISI level of the two groups was obviously lower than before anesthesia (P ＜ 0.05).2h after anesthesia,IRI,IL-6 and TNFα levels of group B were obviously higher than those of group A,and ISI level was obviously lower than group A (P ＜ 0.05).Conclusion Compared with isoflurane,propofol anesthesia can lessen stress reaction and insulin resistance caused by surgical trauma to some extent.But both propofol and isoflurane can not completely relieve stress reaction and insulin resistance