Relationship between Gene Polymorphism of Factor VII R353Q and Cerebral Palsy for Han Chinese Children / 中国康复理论与实践

ABSTRACT

Objective To investigate the relationship between gene polymorphism of factor VII R353Q (FVII R353Q) and cerebral pal-sy for Han Chinese children. Methods Polymerase chain reaction-restricted fragment length polymorphism were used to determine geno-type and allele of R353Q gene in 160 children with cerebral palsy and 137 normal children. Results The genotype of FVII R353Q is close to Hardy-Weinberg equilibrium in both CP group and control group (P>0.05). There was not significant difference in the distribution of the al-lelic frequency and genotype of FVII R353Q between the both groups (P=0.436, P=0.182, respectively). Conclusion The gene polymor-phism of FVII R353Q is not significantly related with cerebral palsy for Han Chinese children.