Roles of hypoxia and Notch1 in multiple myeloma / 国际肿瘤学杂志
Journal of International Oncology
;
(12): 542-546, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-438949
ABSTRACT
Recently numerous studies have demonstrated that Notch signaling pathway plays a critical role in regulating cell proliferation and differentiation in hematopoietic microenvironment,which is associated with MM occurrence and the drug resistance.The latest researches show that there are close relations between hypoxia and Notch signaling pathway in tumor occurrence and progression.Exploring the interactions of microenvironment of hypoxia,HIF-1α and Notch signaling pathway will provide theoretical basis for MM targeted therapy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of International Oncology
Ano de publicação:
2013
Tipo de documento:
Artigo
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