Research progress of CD147 expression in the bone metastases of tumors / 肿瘤研究与临床

ABSTRACT

CD147,which belongs to the immunoglobulin superfamily,is widely expressed in human cells and tissues and is involved in various physiological processes.CD147 has been confirmed as an increased expression in a variety of tumor cells both in vitro and in vivo.It regulates the tumor invasion,metastasis,and the activation of osteoclasts in the process of bone metastasis.Its relationship with bone metastases is one of the hot spots of tumor cell biology research field recently.