Clinical efficacy and safety of abraxane in alternative chemotherapy plan of metastatic breast cancer / 中国综合临床

ABSTRACT

Objective To investigate the therapy effect and adverse reaction of the abraxane chemotherapy as a alternative plan in metastatic breast cancer.Methods Twenty-one patients with advanced metastatic breast cancer were selected as our subject.All the patients received rescue chemotherapy after relapse and metastasis.Abraxane were administrated with 260 mg/m2 3 weeks/time,and evaluated the effect in every two course of radiotherapy.Results Of 21 cases,4 cases were remission and 8 cases were with stable progress of cancer.No allergic reaction occurred.The majority adverse reaction were granulocytopenia and nerve toxicity.Conclusion Abraxane migh be considered as the altemate therapy medicine of metastatic breast cancer due to good curative effect,less toxicity reaction and no allergic reaction.